Isochoric Supercooling Organ Preservation System

نویسندگان

چکیده

This technical paper introduces a novel organ preservation system based on isochoric (constant volume) supercooling. The is designed to enhance the stability of metastable supercooling state, offering potential long-term large biological organs at subfreezing temperatures without need for cryoprotectant additives. Detailed designs and usage protocols are provided researchers interested in exploring this field. also presents control thermodynamics freezing, utilizing pressure monitoring process control. Sham experiments were performed using whole pig liver sourced from local food supplier evaluate system’s ability sustain ice nucleation extended periods. results demonstrated sustained tissue 24 48 h. These findings suggest technology large-volume, cryoprotectant-free with real-time over process. simplicity device design details expected serve as encouragement other field pursue further research However, final evidence that these preserved can be successfully transplanted still lacking.

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ژورنال

عنوان ژورنال: Bioengineering

سال: 2023

ISSN: ['2306-5354']

DOI: https://doi.org/10.3390/bioengineering10080934